Searchable abstracts of presentations at key conferences on reproductive biology and medicine

ra0001p278 | (1) | WCRB2014

Bovine placental lactogen is cleaved by matrix metalloproteinases and resulted 25k N-terminal fragments inhibit the proliferation of vascular endothelial cells

Sasaki Shobu , Hayashi Ken-Go , Hosoe Misa , Kizaki Keiichiro , Hashizume Kazuyoshi , Takahashi Toru

Bovine placental lactogen (bPL) is a classical member of a prolactin (PRL) gene family expressed in the placenta. bPL exerts lactogenic activity similar to pituitary PRL, however, detailed information about the role of bPL during bovine gestation is still limited. The 16 k N-terminal fragments of PRL, generated by enzymatic cleavage, have angiostatic activities in human and rodents. In the present study, we examined the feasibility of N-terminal fragments of bPL following clea...